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In clinical, a prolonged survival by metformin was only observed in diabetic PDA patients and no effect was found in the whole PDA population, which indicates the major effect of metformin is decreasing insulin resistance rather than anticancer effect ( (3)

Gutorgan axis: a microbial outreach and networking

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Afamelanotide, via Scenesse, benefits from a well-characterized safety profile in EPP therapeutic use: controlled cutaneous hyperpigmentation, rare digestive effects, no major cardiovascular signal

Experts warn that intermittent use starting and stopping therapy could undermine benefits and potentially expose patients to new risks