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Laboratory innovations of particular value towards Mojsovs goals included a new resin support called PAM, new side-chain protecting groups, and a new low-high HF cleavage procedure that, individually or in tandem, overcame identifiable limitations associated with the Boc paradigm and its reliance on HF under standard conditions

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Precooled methanol-water (80%, vol/vol) was added to the cell pellets, and the cells were scraped off with a cell scraper into a 2-mL centrifuge tube with ring- d 5 -labeled-phenylalanine added as an internal standard

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6 weeks 6 vials ~25.2 mg total peptide needed

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