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J Clin Invest 123(9):36783684 Herranz D, Ambesi-Impiombato A, Sudderth J et al (2015) Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia

With advances in mechanistic understanding and translational tools, ferroptosis is poised to become a promising therapeutic breakthrough in the precision treatment of Alzheimers disease

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For example, pharmacokinetic modeling and dose escalation studies can help establish appropriate drug concentrations and administration schedules