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However, the -helical extension in TM1 of GIPR provides additional residues for tirzepatide recognition including one hydrogen bond (Y10 P and Q138 1.40b ) and a stacking interaction (K16 P and F127 1.29b )

Thirty minutes later, the mice were allowed to feed, and both food intake and body weight were recorded at 1, 2, 4, 6, and 24 hours post-refeeding

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Kawaguchi T, Konishi M, Kato A, et al

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