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This mechanism is also relevant to minoxidil's effect on hair, though the pathways differ: minoxidil acts as a vasodilator that widens existing blood vessels, while VEGF upregulation promotes the formation of new ones

Together they revealed a common biology of reward that links addiction, food, obesity, B.E.D., and now GLP-1 therapeutics

Incorporating exercise can also improve blood circulation

In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts