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Inducible reporter assays, especially luciferase reporters, which are linked to the activation of specific signaling pathways for example by the GIP receptor, provide a reliable measurement of the inhibitory or activating effect of substances on diabetes-associated cell signaling pathways (Fig

112 Guerreiro G, Amaral AU, Ribeiro RT, Faverzani J, Groehs AC, Sitta A, Deon M, Wajner M, Vargas CR (2019) l-Carnitine prevents oxidative stress in striatum of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload

The reason for this is that the glutathione in many foods is broken down in the gut and poorly absorbed