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Self-administration could lead to incorrect technique or adverse reactions

Aging Dis 12(4):1070 Rumi J, Marmol F, Sanchez J, Gimnez-Crouseilles J, Carreo M, Bargall N et al (2013) Oxidative stress markers in the neocortex of drug-resistant epilepsy patients submitted to epilepsy surgery

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In contrast, however, no noticeable effects on survival, hatching rate, changes in locomotor activity, or signs of oxidative stress were observed

But it was just really clouded and it was a little chaotic, and so that got buried