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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

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Also, a substantial decrease in glutathione levels precedes the mitochondrial dysfunction and neuronal death found in Parkinsons disease, suggesting GSH depletion may initiate the subsequent impairment.It also suggests that increasing GSH levels may have potential benefit toward preventing diseases associated with mitochondrial dysfunction