450 Experimentally reducing astrocyte calcium signalling in striatal circuits induces OCD-like repetitive behaviours in rodents
BCAA metabolism also requires liver and kidney involvement, potentially creating additional burden on these vital organs when they're already working to clear infection-fighting medications
Our bodies do not make vitamin b12, we consume it in our diet
Community reports suggest subjective changes (energy, recovery) may emerge within 1-2 weeks, with more noticeable effects over 4-6 weeks
Beyond FSP1 there are therapeutic opportunities across the CoQ 10 oxidoreductase network While FSP1 currently has the strongest targetability signal, other CoQ 10 oxidoreductases may be therapeutically leveraged in defined genetic, metabolic or tissue contexts: (1) DHODH axis (mitochondrial defense in select contexts): DHODH connects pyrimidine synthesis to mitochondrial CoQ reduction, and in some settings, DHODH inhibition has been proposed to heighten ferroptosis sensitivity, especially in GPX4-low states