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By modulating macrophage polarization towards an M2 subtype, GLP-1RAs can inhibit inflammation occurring in the vessel lumen, an action which would alleviate the progression of atherosclerosis (Figure 2)

rapid serum degradation) ~5 minutes (native peptide, rapid ACE2/neprilysin degradation in plasma) ~2-8 minutes (plasma)

Spitz FR, Kataoka M, Sarkiss M, Meyn R, McDonnell TJ, Swisher S , Cristiano RJ, Roth JA

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In addition, we observed a reduction of KLF2 along with ERK5 degradation, which is a known downstream target gene of ERK5 (Fig