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Some lean mass reduction occurs during any meaningful weight loss but this is better understood as adaptive body remodeling , not muscle wasting. Lets unpack what the science shows

Each additional receptor target adds a new dimension of metabolic activity

However, the most significant changes in body weight generally occur after several months of consistent use

For people using GLP-1 drugs for weight loss, 45% plan to use them long-term, but more (51%) are likely to go on and off based on their needs

There have, however, been anecdotal reports of patients who stop taking one of these medications because their insurance stops covering it or they switch to a new insurance company (say, due to a job change) and can no longer get coverage