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Put simply, semaglutide works by stimulating GLP-1 (glucagon-like peptide-1) receptors, which are responsible for appetite and food intake regulation

This may include eating balanced meals with a focus on whole foods, fruits, vegetables, lean proteins, and whole grains

By expecting gradual results, not overnight change, individuals can better navigate the emotional side of a semaglutide weight loss journey

Some people may also experience fatigue or digestive changes as the body readjusts to normal hormone levels

Out of these, 803 participants who reached the semaglutide maintenance dose were randomized to 48 weeks of continued subcutaneous semaglutide or switched to placebo, both with lifestyle intervention