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Formulation, optimization, and evaluation of allopurinol-loaded bovine serum albumin nanoparticles for targeting kidney in management of hyperuricemic nephrolithiasis: formulation, optimization, and evaluation of ABNPs for kidney targeting

Michael Mimlitz, MD (NPI 1508891870), Chief Physician of GOAL.MD

The nicotin in the name is vitamin B3 etymology and bears no relationship to nicotine, a clarification I make at the start of every consult

The appeal of combining these compounds lies in their synergistic roles in cellular health

This leads to a dysfunction in ATP-dependent ion transport processes, culminating in increased intracellular and mitochondrial calcium levels (calcium overload), cellular swelling, rupture, and cell death via various pathways including necrosis, apoptosis, and autophagy