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In a systematic review and meta-analysis of four randomized controlled trials including over 3,700 subjects, combination therapy with an SGLT2 inhibitor and metformin beginning at diabetes diagnosis resulted in greater weight loss and reduction of HbA1C levels compared with either drug alone

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l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents

Jul 29 2020;12(8)doi:10.3390/nu12082276

Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway