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People with Deficiencies : Individuals diagnosed with B-vitamin deficiencies due to poor diet, malabsorption conditions, or alcohol dependence

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease

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Peptide identity, correct disulfide folding, endotoxin content, and actual concentration can vary, which further undermines any attempt to reason about effects in a living organism from an uncharacterized preparation