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GSH may rapidly oxidize to glutathione disulfide (GSSG) under oxidative stress, but under normal conditions, it is reduced back to GSH by glutathione reductase (GR) via an reductant nicotinamide ademine dinucleotidephosphate (NADPH) -dependent mechanism both in the cytosol and mitochondria to maintain the GSH/GSSG balance [6]

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Volkow ND, Wang GJ, Fowler JS, Hitzemann R, Angrist B, Gatley SJ, et al

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This cascade establishes a self-perpetuating vicious cycle, wherein systemic inflammation exacerbates gut barrier dysfunction and dysbiosis, which then further fuels the inflammatory response