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Epub 2017 Jul 24..10.1016/j.kint.2017.05.003 [PubMed: 28750928] [CrossRef] 302

These increases occurred within four months after the start of treatment and continued during treatment periods of up to three years

It was reported that BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels (Patel et al., 2016), and CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research

Since IGF-1 is similar to insulin in terms of molecular structure and even function, its presence in the body can alter how the body reacts to insulin responsible for regulating blood glucose levels

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes C colorectal carcinoma