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164 Although these facts suggest that hemostatic problems are common in patients with liver disease, discordance is often noted between degree of abnormality of laboratory tests of coagulation and clinical evidence of bleeding.260,446,455 Even in patients bleeding from esophageal varices and having prolonged clotting times, administration of blood components (including activated factor VII) was not associated with any clinical difference in degree of bleeding or need for blood transfusions

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DOI:10.1016/S0006-3223(97)00277-1 5

Pattern 4: The "energy crash" at week 10-12

doi: 10.1158/1538-7445.AM2024-2149 153 YoriokaMAWMurtaCBLeiteKRMCardiliLde MelloESde Carvalho FazoliAJet al