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It is most often caused by an iron deficiency, but also of other micronutrients such as vitamin B12
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Notably, combination treatment induced a higher polyfunctionality of CAR-T cells with increased cytokine composition of co-secreting IFN-, granzyme B, and perforin, etc., at single-cell level in vitro compared with each treatment (Supplemental Figure 7, C and D) and enabled improvement of antitumor activity of CAR-T cells in NOD scid gamma (NSG) mice bearing HCC-1806 tumors (Figure 4, T and U)
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