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Moreover, MAPK/ERK signaling upregulates Kruppel-like factor-2 (KLF2) and KLF4, which enhance eNOS expression, inhibit NF-B signaling, and suppress TNF- receptor expression, reinforcing anti-inflammatory and atheroprotective effects [207]

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While not as rapid as C8, it still supports metabolic rate and energy levels, contributing to fat burning and weight loss

Clinical trials show that discontinuing GLP-1 therapy leads to weight regain in approximately 70% of patients within one year, underscoring why these medications function best as long-term treatment rather than temporary interventions

What Are GLP-1 Medicines