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Oxidative stress occurs when oxidants (reactive oxygen species) outweigh available antioxidants

The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison

Acne is a symptom, not a cause

The timing question that applies to GLP-1 medications broadly applies here as well, and the answer is largely personal preference