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[2] The formulation that reached controlled human testing, and the only one for which a controlled human trial is retrievable, was a topical gel

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Link Bhanumathy, M., et al

Together, these results suggest that sleep and sleep deprivation bi-directionally can impact the molecular signalling pathways that regulate synaptic strength and control brain plasticity, supporting the hypothesis of a direct relation between cortical plasticity and sleep regulation ( Figure 4 )

Study authors reported that IGF-1 in the older men increased by 25% with the highest dose, reaching levels observed in the untreated younger individuals