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Growth media was replaced with binding buffer [phenol-free DMEM containing 25 mM HEPES and 0.1% (w/v) BSA] containing 0.7 nM 125 I-Ex(939) or 0.15 nM 125 I-hGLP-1 and increasing concentrations of unlabelled ligand

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The result: severe water retention, numbness and tingling in the hands (carpal tunnel symptoms from excessive GH), facial flushing, and paradoxically reduced GH output as the pituitary downregulates its response

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From there, your provider will discuss your weight loss goals and develop a tailored plan