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The Limitations of Skin Calipers Youve probably seen those pincer-like tools that personal trainers use to pinch your skin at various spots on your body

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Lancet 2: 20-21, 1964

Note there are 2 large randomized trials of semaglutide for Alzheimers disease expected to report out in 2026

Importantly, localized increases in GLP-1, such as that occur in the gut and portal vein, often have a more profound effect than systemic elevations, emphasizing the therapeutic potential of targeting regional activity rather than relying solely on systemic concentrations