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Modifications in gene expression occur to yield an increase in the content of HSP [30, 31], proteins that act as molecular chaperones, being crucial in helping the cellular remodelling processes of denatured proteins, independent of the training response [89, 91]

This indicated a lower influx of proline into the TCA cycle via the glutamate to -ketoglutarate route

After 1:1 propensity score matching, there were 3,048 patients in each cohort