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After AIS, sympathetic nerve tension increases, and sustained overexcitation of the sympathetic nerve network leads to substantial catecholamine release

68 Diabetic cerebral microangiopathy has multiple complex changes in images (cerebral atrophy, subcortical microinfarcts, cerebral white matter hyperintensity, lacunar infarction, perivascular space, and cerebral microhemorrhage), 69 with diffuse adverse effects

This theoretically preserves the cytosolic pool of NAD+ (Nicotinamide Adenine Dinucleotide), which is critical for sirtuin activation and mitochondrial oxidative phosphorylation

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