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The medication is administered once weekly via subcutaneous injection, with doses gradually titrated upwards to minimise gastrointestinal side effects

The difference in the means is not statistically significant as analysed by two-tailed t -test

Reinforcing this, in heart failure with preserved ejection fraction, randomized trials such as the STEP-HFpEF program published in the New England Journal of Medicine demonstrated improvements in symptoms and physical limitations, with benefits that could not be fully explained by weight loss alone

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Fat Metabolism : GLP-1R agonists have been shown to influence fat oxidation and improve lipid metabolism , supporting fat loss and improving body composition