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Studies have found that berberine can effectively alleviate the motor dysfunction of HTT mice and prolong their survival time, further studies proves that berberine promote the degradation of mutant HTT protein through enhancing autophagy function, thereby reducing the accumulation of mutant huntingtin protein (Jiang et al., 2015b)

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IL-1 and TNF trigger the activity of phospholipase (PL) A2, COX-2, and nitric oxide (NO) synthase that increases the production of platelet-activating factor, leukotrienes, prostanoids and nitric oxide