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About GLP-1 and Dual GLP-1/GIP Agonists Activation of the glucagon-like peptide 1 (GLP-1) receptor has been shown to decrease glucose, reduce appetite, lower body weight, and improve insulin sensitivity in patients with type 2 diabetes, obesity, or both

The clinical success of dual and triple incretin agonists has validated the concept that engaging multiple complementary pathways within a single molecular framework can yield superior efficacy without proportionally increasing toxicity ( 3.3 Improved tools for mechanistic validation and risk de-risking Technological advances have also improved the ability to de-risk peptide systems earlier in development

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Eur J Clin Pharmacol, 1992