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When M1 MEVs are introduced into the tumor microenvironment, they influence the surrounding M2 macrophages to adopt a more pro-inflammatory, tumor-fighting state by increasing the secretion of cytokines such as TNF- and upregulating pro-inflammatory markers like CXCL8

According to a 1961 study, patients with addiction who got NAD+ at a moderate IV drip rate (no more than 35 drops per minute) reported "no distress" but those who received it at a quicker drip rate complained of headache and shortness of breath (18)

doi: 10.1016/j.nut.2005.06.003

Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage