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This can lower the body's ability to fight damage from free radicals

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Glucagon also contributes to energy homeostasis by promoting satiety through vagal signaling to brainstem nuclei and by increasing resting energy expenditure through facultative thermogenesis in brown adipose tissue, skeletal muscle, and through promotion of WAT browning [22]

One class of cardiac glycosides, cardenolides, are found in multiple plant families, and evolved in the genus Erysimum of the Brassicaceae family between one and three million years ago, providing defense against glucosinolate (a different class of defensive metabolite)-resistant insects