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In clinical practice, providers often observe that patients who progress steadily through lower stages without significant gastrointestinal symptoms tend to tolerate increases toward higher tiers more comfortably than those who experienced ongoing discomfort earlier in treatment

Geographic disparities are evident, with low- and middle-income countries facing amplified risks due to infrastructure and regulatory gaps

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It also plays an important role in heart, and eye health and strong skin, hair, nails, and bones