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If a stone forms because of the medications direct effect on the kidneys, that is one concern

[DOI] [PubMed] [Google Scholar] 47.Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, et al

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LDL-C may contribute to the onset of AF by exacerbating atherosclerosis, causing myocardial ischemia and structural heart changes (e.g., left atrial enlargement or fibrosis), and the ARIC study demonstrated a significant correlation among high LDL-C levels and AF occurrence [107]

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