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Notably, the decrease in BW and improvement in body mass composition were not associated with less food consumption as both SR4 treatment and control demonstrated similar daily food intake (Fig

Moreover, in comparison to wild-type psoriatic mice, NRF2-deficient psoriatic mice exhibited an increase in the expression of Il17a and Il23a in skin tissues

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Most side effects are mild and temporary , and they usually settle after the first few weeks as your body adjusts

Notably, participants had not reached a weight loss plateau by the end of the 48-week study, suggesting that the full weight loss potential of retatrutide may extend beyond this timeframe