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In the kindling model, chronic administration of subconvulsive doses of PTZ initiates the recurrence of seizures in a similar manner to the human epilepsy more than the acute models, where the seizure severity increases in a stepwise manner with each PTZ injection inducing severe generalized tonic-clonic seizures (Shimada and Yamagata 2018)

And while the drugs label showed that semaglutide had a small effect on the levels of ethinyl estradiol/levonorgestrel in patients systems, it wasnt enough of an effect to warrant a dosage change recommendation

doi:10.1007/s42399-025-01814-6

doi: 10.1177/26330040211065453

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