11.5 Pharmacokinetics and bioavailability It is evident that following oral administration, resveratrol is rapidly absorbed in the gastrointestinal tract (75%) with an extensive first-pass metabolism in the intestine and liver, lowering its oral bioavailability (ranging from 2.6 to 75% in humans and 2029% in rats fed 50 mg/kg) [198]
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Ursini F, Heim S, Kiess M, Maiorino M, Roveri A, Wissing J, Floh L
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It's important to watch for these signs and talk to a doctor