Kardie Tobb, DO, MS, FASPC, FACC, a boardcertified preventive cardiologist and the medical director for the Cone Health HeartCare Womens Heart Health and Cardio-Obstetrics Clinic, explains some of the most common reasons why GLP-1s may not deliver the results youre hoping for, including: You need a higher dose and have not yet reached a therapeutic dose as determined by your doctor High intake of liquid calories , including alcohol and ultra-processed foods Not getting enough protein , which can leave you persistently hungry and makes it harder to feel full Advanced diabetes or insulin resistance Taking other medications such as sulfonylureas, which lower blood sugar but can lead to weight gain Not adhering to your dosing schedule , such as inconsistent weekly injections or missed doses Differences in gut hormones or genetics And just because your GLP-1 isnt working immediately doesnt mean it wont work for you

Author contributions JX: Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing original draft
The incidence of nausea was as follows: placebo: 7.7%
We can't stress this enough: even if you plan to reconstitute the vial within a few weeks, putting it in the freezer immediately is the best practice
[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Tipa R.O., Balan D.G., Georgescu M.T., Ignat L.A., Vacaroiu I.A., Georgescu D.E., et al