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Microscopy Retrobulbar application of L-NAME resulted in degeneration of ganglion cells and in nerve cell layer narrowing of the blood vessel lumen (using immunohistochemistry for Factor VIII)

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Similar to AD and PD, accumulating evidence suggests that compromised mitophagy lead to the progression of other neurodegenerative diseases, such as HD, ALS, and spinal muscular atrophy (SMA) [136,137,138]

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