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In a mouse model of epilepsy, disruption of urate oxidase activity reduced susceptibility to pentatetrazole- and pilocarpine-induced epilepsy, possibly through a chronic increase in uric acid levels leading to decreased brain excitability (75)

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General immune-related pathways included regulation of JNK cascade, inactivated in all 3 cell lines, and systemic lupus erythematosus, activated in DU145 and 22Rv1 and containing many complement, Fc receptor and HLA encoding genes (www.genome.jp/entry/pathway+hsa05322)

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