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Summary: Vomiting on GLP-1 medications occurs because these drugs slow gastric emptying and stimulate receptors in the brainstem that trigger the vomiting reflex

For example, it reduces oxidative stress, reduces cell damage in alcoholic & nonalcoholic fatty liver disease, improves insulin resistance, and much more

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SC administration offers practical advantages: Potential for self-injection at home No requirement for clinical infusion center Simpler logistics for chronic dosing Better patient compliance for long-term treatment Clinical Trial Dosing# COURAGE Trial (Phase 2, Obesity)# COURAGE Triplet Arm# Phase 1 Trial (NCT02943239)# Dose Comparison Across Studies# Dosing Considerations# No Clear Dose-Response for Trevogrumab Alone# In the COURAGE trial, both the 200 mg and 400 mg trevogrumab doses showed remarkably similar lean mass preservation (50.8% vs 51.3%), suggesting that myostatin blockade alone may have a ceiling effect

Patient is on day 3 of IV antibiotic (mainly initiated in acute care)