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Maybe you think the dose needs adjusting

A 2021 New England Journal of Medicine study found that combining semaglutide with lifestyle interventions, including exercise, led to an average 14.9% weight loss over 68 weekssignificantly more than lifestyle changes alone

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Konstantinova, Svetlana V., et al

But NAD+ metabolism is a complex process, and while you can ramp up NAD+ production with a lone precursor, fueling other aspects of the production process can make your NAD+ increases more efficient and sustainable.2 NMN and NR both effectively raise NAD+ levels, but each one has exhibited some other effects in human studies that haven't been replicated in studies of the other