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Specifically, eligibility requires BMI 30 kg/m independent of other conditions, or BMI 27 kg/m in the presence of at least one weight-related comorbidity such as hypertension, type 2 diabetes, or cardiovascular disease

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They have also been modified so that DPP-4 cannot metabolize them

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Its absence can upregulate SLC7A11, promoting cell migration and invasion, while inhibition of SLC7A11 can reverse this phenotype, indicating that NudCL2 can inhibit epithelial-mesenchymal transition (EMT) by regulating the transcriptional activity of SLC7A11