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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

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For most individuals starting a combined protocol, basic ice packs or cold water immersion provides sufficient cryotherapy benefits without major investment

doi:10.1016/S0141-1136(97)00071-8