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Current Anti-Obesity Pharmacotherapy The oldest medication approved for chronic weight management, orlistat, is a reversible inhibitor of gastric and pancreatic lipases that works to impair fat absorption from the gut

Because response and tolerability vary, clinician-guided dosing and patient education are essential to ensure appropriate use, manage potential side effects, and establish realistic expectations for treatment outcomes

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GLP-1 medications are designed to help regulate appetite, reduce cravings, and improve feelings of fullness

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