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After 48 weeks, 36%-48% of subjects receiving 8 mg and 12 mg doses achieved 25% weight reduction, with no participants in the placebo group reaching this level
This discrepancy may be attributed to several alternative, non-mutually exclusive hypotheses that must be considered with equal weight: (1) a misalignment between the drugs therapeutic window and the disease stage of the enrolled patients (the prevention hypothesis)
Uses Semaglutide is used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity
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Oral semaglutide 25 mg achieved 16.6% mean weight loss at 64 weeks for patients who stayed on treatment, and one-third of adherent participants lost at least 20% of their body weight, versus under 3% with placebo
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