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In SELECT, the separation in cardiovascular event curves between semaglutide and placebo emerged early , before patients had accumulated the kind of weight loss that could plausibly explain the protection through metabolic pathways

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J Cell Biol 167(2):223229 Hofer E, Schweighofer B (2007) Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis

M1 macrophages are pro-inflammatory and produce cytokines such as IL-1, IL-6, IL-12, and TNF-