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A pooled analysis of the SUSTAIN 6 and PIONEER 6 trials, which studied semaglutide in diabetic patients, demonstrated that treatment effects on MACE remained similar when accounting for body weight changes
This clearly shows that semaglutide is most effective as part of a long-term weight loss management plan
Further analysis looked at whether a greater weight loss led to even more benefits, but results showed that the benefits were seen regardless of starting weight or how much weight participants lost
This update follows reports of adverse effects such as nausea, vomiting, and abdominal pain among users
Complete absence of appetite suppression after reaching 2.4mg for at least four weeks suggests you may not respond to semaglutide
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