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A larger trial-emulation study (SURPASS CVOT NCT06779929) found both medicines offered broadly comparable heart protection in high-risk adults with type 2 diabetes

GLP-1 medications are generally considered safe when used under proper medical guidance

To date, several of the randomized controlled trials (RCTs) have been conducted either in the elderly or in individuals with pathological conditions like Alzheimers disease

If nausea or other GI side effects persist beyond 4-6 weeks despite dose stabilization, provider guidance should address whether to continue, adjust the formulation, or transition to an alternative

Some patients do regain weight after stopping GLP-1 medications, which is one reason they may consider bariatric surgery as a longer-term treatment option.