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Accordingly, elevated expression of IRS-1 s312 has been found in post-mortem studies of patients with PD 14 , Alzheimers Disease (AD) 10 and Multiple System Atrophy (MSA) 15 , in association with severe dopaminergic depletion in the caudate and ventral striatum 5,16 , frontotemporal cortical atrophy 17,18 , and lower cerebral glucose hypometabolism 19

The results of a study carried out in 2013 indicated that trend