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As of September 2023 it is on the FDA's Category 2 list of bulk drug substances that may not be compounded due to significant safety risks, and the agency has scheduled a Pharmacy Compounding Advisory Committee (PCAC) review for July 2026 covering proposed uses in opioid withdrawal, chronic insomnia, and narcolepsy

269 The benefits of TZDs in MASLD and fibrosis may be the increased adiponectin levels and the adiponectin-mediated effect on insulin sensitivity and hepatic fatty acid metabolism 270 and the downregulated fibrogenic factors and related pathways, inflammatory pathways like JAK/STAT and NF-B signaling pathways

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